Introduction to the InnerEarLab
The InnerEarLab explores sensory processing in the inner ear during normal and impaired
function. A common focus of the groups in the InnerEarLab is on sensory encoding in the
inner ear by specialized synapses the hair cell ribbon synapses. We combine various
techniques for studying the molecular anatomy and physiology of these synapses. The group of
Carolin Wichmann studies the molecular ultrastructure of synapses using light and electron
microscopy. The group of Tobias Moser uses patch-clamp, optical methods, and biophysical
modeling to study structure and function of hair cell ribbon synapses and the endbulb of
Held synapse in the cochlear nucleus. The group of Tina Pangršič Vilfan studies the
molecular and cellular basis of noise-induced hearing loss as well as vestibular
neurotransmission. The group of Nicola Strenzke studies auditory systems physiology at the
single neuron and population levels. The group of Christian Vogl explores the development of
inner hair cell ribbon synapses. The Beutner group studies middle ear mechanics using
contact-free measurements by laser-doppler vibrometer. Thomas Effertz with his group studies
the molecular function of mechano-electrical transduction. The Moser and Strenzke groups
also work on establishing optogenetic stimulation of the auditory nerve as a tool for
auditory research and improved hearing restoration by cochlear implants, which is also a
focus of the work of the Wrobel group, who additionally work on the recovery of the damaged
auditory nerve. The Beutner, Moser, and Strenzke groups also perform clinical research.