The Institute for Auditory Neuroscience of the University Medical Center Göttingen (Germany) invites applications for a
PhD-Student Position in Synaptic Neuroscience
Mammalian sound encoding relies on faithful and precise neurotransmission between cochlear inner hair cells (IHC) and afferent spiral ganglion neurons. To master this challenging task, the presynaptic active zones of IHCs are equipped with presynaptic specialisations – due to their morphology termed 'synaptic ribbons' – that facilitate high rates of vesicular release and subsequent replenishment, even during prolonged periods of ongoing stimulation. While the molecular architecture and function of ribbon-type active zones has been an area of intense research, the presynaptic development prior to hearing onset still remains enigmatic. Hence, this project will focus on developmental aspects of presynaptogenesis in auditory hair cells and aims to identify the key molecules, as well as the underlying cellular processes that determine the functional maturation and presynaptic plasticity of this high-throughput synapse.
We are looking for highly motivated applicants with a strong background in neuroscience and/or live-cell imaging; additional experience in molecular biology or programming skills are of advantage. Moreover, the ability to work in an interdisciplinary (i.e. combining molecular, ultrastructural and physiological approaches) and international research team is an essential prerequisite. This position is supported by an Otto-Creutzfeldt fellowship of the Helmut & Elisabeth Uhl Foundation and available for 3+ years. Income will be equivalent to E13 65%.
The Göttingen Campus is a leading Neuroscience Center hosting numerous internationally renowned research institutions. This includes the University and its Medical Center, three Max Planck Institutes, the European Neuroscience Institute, and the German Primate Center. The Institute for Auditory Neuroscience & InnerEarLab offers a stimulating multidisciplinary research and training environment and operates state of the art research infrastructure. Moreover, the institute is tightly integrated in the Campus with research groups hosted also at non-university institutions and runs numerous productive collaborations on Campus such as within the collaborative sensory research center SFB 889 , the Bernstein Center for Computational Neuroscience (BCCN) and the Center for Nanoscale Microscopy and Molecular Physiology of the Brain (CNMPB), as well as beyond the Campus.
Please submit your application preferably in one single PDF-document, including cover letter, CV, list of publications, names of possible referees, and relevant certificates to: firstname.lastname@example.org until October 15th, 2017.
Institute for Auditory Neuroscience and InnerEarLab
University Medical Center Göttingen
The Synaptic Nanophysiology Group at MPI for Biophysical Chemistry invites applications for a
PhD position in Synaptic Biophysics
The successful candidate will conduct experimental research on the molecular anatomy and physiology of synaptic transmission at the endbulb and calyx of Held synapses of the auditory pathway. Using state of the art electrophysiology (pre- and/or postsynaptic patch-clamp, capacitance measurements) and optical methods (uncaging, confocal, 2-photon, and STED imaging) in combination with genetically manipulated animals, the project targets fundamental questions in synaptic transmission, such as:
How is the tight coupling of Ca2+-influx and exocytosis at the presynaptic active zone achieved on a molecular level?
What are the molecular mechanisms mediating efficient replenishment of synaptic vesicles to the presynaptic active zone?
We are looking for excellent and highly motivated applicants with a strong background (first degree) in physics, biology, or neuroscience and, ideally, experience in biophysical techniques. Competence in electrophysiology and state of the art light microscopy will be useful. Good computational skills and the ability to work in an interdisciplinary (combining molecular, structural, physiological, and theoretical approaches) and international team of researchers are required. Prior knowledge in theoretical neuroscience is welcome.
The project is part of the collaborative research center 1286 “Quantitative Synaptology” and the wider Göttingen Campus, which is a leading neuroscience center in Europe hosting numerous prestigious and internationally renowned neuroscience research institutions. This includes the University, three Max Planck Institutes, the European Neuroscience Institute, and the German Primate Center, as well as further collaborative research programs.
Please submit your application preferably in one single PDF-document, including cover letter, CV, list of publications (if applicable), names of possible referees, and relevant certificates to: email@example.com
Prof. Dr. Tobias Moser
Professor of Auditory Neuroscience
Synaptic Nanophysiology Group
Max-Planck-Institute for Biophysical Chemistry
Am Fassberg 11