The InnerEarLab explores sensory processing in the inner ear during normal and impaired function. A common focus of the groups in the InnerEarLab is on sensory encoding in the inner ear by specialized synapses the hair cell ribbon synapses. We combine various techniques for studying the molecular anatomy and physiology of these synapses. The junior group of Ellen Reisinger deals with the molecular biology and genetics of cochlear neurotransmission, studying gene expression, protein biochemistry and structure of hair cell synaptic proteins and performs genetic manipulations of hair cells for physiological studies and preparing the grounds for future gene therapy. The junior group of Carolin Wichmann studies the molecular ultrastructure of synapses using light and electron microscopy. The group of Tobias Moser uses patch-clamp, optical methods, and biophysical modeling to study structure and function of hair cell ribbon synapse and the endbulb of Held synapse in the cochlear nucleus. The junior group of Tina Pangršič Vilfan studies the molecular and cellular physiology of vestibular neurotransmission. The junior group of Nicola Strenzke studies auditory systems physiology at the single neuron and population levels. The group of Bernstein Fellow Andreas Neef uses experiments and modeling to explore sound encoding at the microscopic scale. The Canis group studies cochlear blood flow using intravital microscopy and pharmacology. The Moser and Strenzke groups also work on establishing optogenetic stimulation of the auditory nerve as a tool for auditory research and improved hearing restoration by cochlear implants. The Canis, Moser, and Strenzke groups also perform clinical research.

ContactUs

InnerEarLab
Institute for Auditory Neuroscience
Department of Otolaryngology
Sensory Research Center SFB 889
Center for Molecular Physiology of the Brain
Bernstein Center for Computational Neuroscience
University Medical Center Goettingen
D-37075 Göttingen

Tel: +49 (0)551 3922837
Fax: +49 (0)551 3912950

Press Release

  • „Internationale Tagung in Göttingen
    Molekulare Grundlagen des Hörens“ [more]
  • „Internationale Tagung zu molekularen Grundlagen des Hörens in Göttingen“ [more]
  • „Göttinger Forscherteam entwickelt optogenetische Cochlea-Implantate“ [more]
  • „"InnoTruck" stoppt in Göttingen“ [more]
  • „Fast channelrhodopsins for optogenetic hearing restoration“ [more]
  • „InnoTruck in Göttingen“ [more]
  • „Schnelle Lichtkanäle befeuern das Hören“ [more]
  • „Beat the Prof: Was ist das absolute Gehör?“ [more]
  • „Uni Göttingen will wieder Exzellenz-Uni werden“ [more]
  • „Start-up "OptoGenTech" Licht soll taube Menschen wieder hörend machen“ [more]
  • „"Lichtsteuerung“ für Zellen: Projekt OptoGenTech am Photonik Inkubator Göttingen genehmigt“ [more]
  • „Optische Vermessung der Nano-Welt“ [more]

Recent Publications

  • High frequency neural spiking and auditory signaling by ultrafast red-shifted optogenetics [more]
  • High-fidelity CRISPR/Cas9- based gene-specific hydroxymethylation rescues gene expression and attenuates renal fibrosis[more]
  • Propagation-based phase-contrast x-ray tomography of cochlea using a compact synchrotron source / in press[more]
  • The synaptic ribbon is critical for sound encoding at high rates and with temporal precision [more]
  • The CAPOS mutation in ATP1A3 alters Na/K-ATPase function and results in auditory neuropathy which has implications for management [more]
  • Quantitative optical nanophysiology of Ca2+-signaling at inner hair cell active zones [more]
  • Glyoxal as an alternative to PFA in immunostainings and nanoscopy [more]
  • Piccolo promotes vesicle replenishment at a fast central auditory synapse [more]
  • RIM-binding protein 2 promotes a large number of CaV1.3 Ca2+-channels and contributes to fast synaptic vesicle replenishment at hair cell active zones [more]
  • Activity-Dependent Phosphorylation by CaMKIIδ Alters the Ca2+ Affinity of the Multi-C2-Domain Protein Otoferlin [more]
  • The BEACH protein LRBA is required for hair bundle maintenance in cochlear hair cells and for hearing [more]
  • Rab interacting molecules 2 and 3 directly interact with the pore-forming CaV1.3 Ca2+ channel subunit and promote its membrane expression [more]
  • Ca2+-binding protein 2 inhibits Ca2+-channel inactivation in mouse inner hair cells [more]
  • Conditional deletion of pejvakin in adult outer hair cells causes progressive hearing loss in mice [more]
  • Hair cell synaptic dysfunction, auditory fatigue and thermal sensitivity in otoferlin Ile515Thr mutants [more]
  • New insights into cochlear sound encoding [more]
  • Hair cells employ active zones with different voltage-dependence of Ca2+-influx to decompose sounds into complementary neural codes [more]
  • Tryptophan-rich basic protein (WRB) mediates insertion of the tail-anchored protein otoferlin and is required for hair cell exocytosis and hearing [more]
  • DNA Diagnostics of Hereditary Hearing Loss: A Targeted Resequencing Approach Combined With a Mutation Classification System [more]
  • Eyes without a ribbon [more]
  • Auditory neuropathy - neural and synaptic mechanisms [more]
  • Disruption of adaptor protein 2μ (AP-2μ) in cochlear hair cells impairs vesicle reloading of synaptic release sites and hearing [more]
  • Reliable encoding and processing of auditory information is mediated by different types of synapses employing distinct molecular and structural mechanisms [more]
  • Gene therapy for deafness: How close are we? [more]
  • Synaptic encoding and processing of auditory information in physiology and disease [more]
  • Relating structure and function of inner hair cell ribbon synapses [more]
  • Rab3-interacting molecules 2α and 2β promote the abundance of voltage-gated CaV1.3 Ca2+ channels at hair cell active zones [more]
  • EF-hand protein Ca2+ buffers regulate Ca2+ influx and exocytosis in sensory hair cells [more]